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#10 St. John’s vs DePaul: Odds, Predictions & Key Insights | February 19, 2025

Written by: Colby Marchio
Last Updated:
Read Time: 4 minutes

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Rick Pitino, DePaul, and a Big East battle—what more could you ask for? The Red Storm have their eyes on a championship, while the Blue Demons are just trying to keep up. With one team surging and the other struggling, there is only one way to play this matchup.
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#10 St. John’s vs DePaul Odds

Will DePaul’s offense be strong enough to handle St. John’s lockdown defense?
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Spread
St. John’s: -13 (-105)
DePaul: +13 (-115)
Total
Over: 142.5 (-110)
Under: 142.5 (-110)
Moneyline
St. John’s: -925
DePaul: +665
#10 St. John’s vs DePaul Best Bet
Boots will be on the ground as I attend to see not only Italian icon Rick Pitino but also my alma mater, DePaul. However, it is bad news for the Blue Demons, as we are riding with their team total under in this Big East rematch. The first meeting between these teams was back in December, when the Red Storm dominated DePaul 89-61, winning by 28 points. Now, with a Big East Championship in their sights, St. John’s heads into Chicago as 13-point favorites, with a massive Sunday rematch against UConn looming.
That said, I do not see a Rick Pitino-led team cruising in this matchup, especially on defense, where they have thrived on the road. Ranked first in adjusted defensive efficiency, the Red Storm are the real deal. They excel at forcing turnovers, ranking 14th nationally, and are top 10 in both two-point defense and block percentage. They have also allowed fewer points on the road (64.5 opponent PPG) than they do at home.
This game will likely be played at DePaul’s pace rather than St. John’s top-60 tempo, setting up a much slower contest than in December. Per Haslametrics, DePaul ranks as low as 218th in pace, making this a different kind of matchup.
Can DePaul Shock the Nation?
Playing at Wintrust Arena has been where DePaul performs best, but even then, its offense remains middle of the pack. The Blue Demons struggle to get to the free-throw line, ranking 306th in free-throw rate offense. They also get their shots blocked at an alarming rate, ranking 322nd in offensive block percentage, and turnovers have been an issue all season. At home in conference play, they sit in the bottom three in adjusted offensive efficiency, effective field goal percentage, turnover rate, free throw rate, two-point percentage, three-point percentage, and offensive block percentage. Tonight, this offense faces one of the best defenses in the country.
In Big East home games, DePaul has only topped 65 points three times. They scored 68 against UConn on January 1, then put up points in their wild overtime loss to Marquette when the Golden Eagles were clearly looking ahead to Xavier. Their most recent success came in a win over Seton Hall, the worst team in the conference. Despite their comfort level at home, they have averaged just 64.1 PPG in conference play, while St. John’s allows only 60.8 PPG on the road in conference.
This is a “tip your cap” game if DePaul somehow goes over its team total tonight because all the data points to them landing around 62 points. Regardless, give me that under!
Best Bet: DePaul Team Total Under 65.5 (-115) on BetOnline
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Former D1 (club) baseball player, Colby has been betting since his college days at DePaul, where he had to endure the worst collegiate basketball the Big East has ever seen. He is an advanced analytics nerd who spends his free time on Bart Torvik, Ken Pom and Batters-Box.com. He has never seen an underdog he has not liked. Hot. Corn. Bull. It does not matter the dog he loves them all.
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