Reds vs Brewers: Odds & Predictions | April 3, 2025

The Reds and Brewers square off in a divisional matchup, with Cincinnati sending left-hander Nick Lodolo to the mound against a Milwaukee lineup struggling with strikeouts. Lodolo has been dominant on the road, while the Brewers lean on William Contreras, their best hitter against left-handed pitching, to spark the offense. With Milwaukee’s strikeout woes and Lodolo’s ability to generate swings and misses, this game sets up as a key test for both sides early in the season.

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Reds vs Brewers Odds

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Runline

Reds: +1.5 (-205)

Brewers: -1.5 (+175)

Total

Over: 8 (-113)

Under: 8 (-107)

Moneyline

Reds: +105

Brewers: -115

Reds vs Brewers Best Bet

The highest-rated pitcher on today’s slate is Reds starter Nick Lodolo. He enters the day with the highest average hitter matchup strikeout percentage and the highest average hitter ground ball rate. Additionally, he ranks second in lowest hard contact allowed.

Last season, Lodolo was significantly better on the road, posting a 3.56 ERA while averaging 7.1 strikeouts per game.

He faces a Brewers team struggling with plate discipline, ranking fourth worst in strikeout percentage to start the year. Eight Brewers hitters are above the league’s strikeout rate, making this a strong opportunity for Lodolo to rack up strikeouts. In half of Milwaukee’s games this season, opposing pitchers have surpassed this strikeout mark.

A few trends stand out for Lodolo. When pitching on the road with an elite rating, he records six or more strikeouts 75% of the time. The sample size is small—just four games—but notable, especially since he lacks impressive home trends. The number seems a bit low, though he is coming off a one-strikeout outing on Saturday despite pitching six innings. He should bounce back against a struggling Brewers lineup.

Best Bet: Nick Lodolo Over 5.5 Strikeouts (-110) at BetOnline

 

 

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Call me crazy, but there is one Brewers hitter we want to see succeed—their lone elite-rated hitter, William Contreras. The Brewers catcher is one of the league’s best against left-handed pitching, boasting a career .318 batting average and a .947 OPS.

When carrying an elite rating, Contreras records at least one hit 67% of the time across a 56-game sample size. He also homers 12.5% of the time (yes, I sprinkled) and goes over this prop 46% of the time.

He has not started the season hot, batting just .100 through six games. However, with a left-handed pitcher on the mound, this is the perfect spot for him to bounce back.

Best Bet: William Contreras Over Total Bases 1.5 (+150) at BetOnline

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